Lead Bioinformatics & Machine Learning Scientist

Natera·US Remote·Remote·Posted 4 November 2026

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About the role

Natera is seeking a Lead Bioinformatics & Machine Learning Scientist to join our Bioinformatics Research team and help build the machine learning models behind Natera's tissue-free, methylation-based assay. These will be the models that detect cancer in the minimal residual disease (MRD) setting and help inform treatment selection. The ideal candidate brings a strong background in algorithm development, genomics, sequencing data processing, and applied machine learning. Primary Responsibilities: Develop, train, and evaluate machine learning models, driving algorithm design decisions that support cancer detection in the MRD setting. Own end-to-end research analyses, from ideation through implementation (scripts and notebooks), troubleshooting, and performance evaluation, including developing new features within existing pipelines. Translate between wet-lab experimental design and computational analysis, navigating ambiguity as assay requirements evolve and maintaining rigorous quality control across high-volume sequencing data spanning multiple cohorts, vendors, and clinical protocols. Communicate findings and model performance to both technical and cross-functional stakeholders,…

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